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Article

Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer.

Cancer research - 1 Nov 2018

Nagathihalli Nagaraj S, Castellanos Jason A, Lamichhane Purushottam, Messaggio Fanuel, Shi Chanjuan, Dai Xizi, Rai Priyamvada, Chen Xi, VanSaun Michael N, Merchant Nipun B

Abstract excerpt

Major contributors to therapeutic resistance in pancreatic ductal adenocarcinoma (PDAC) include Kras mutations, a dense desmoplastic stroma that prevents drug delivery to the tumor, and activation of redundant signaling pathways. We have previously identified a mechanistic rationale for targeting STAT3 signaling to overcome therapeutic resistance in PDAC. In this study, we investigate the molecular mechanisms...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30154150
DOI: 10.1158/0008-5472.CAN-18-0634
PMCID: PMC6878978

Genes

STAT3
AREG
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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