Article
ProGeo-neo: a customized proteogenomic workflow for neoantigen prediction and selection.
BMC medical genomics - 3 Apr 2020
Li Yuyu, Wang Guangzhi, Tan Xiaoxiu, Ouyang Jian, Zhang Menghuan, Song Xiaofeng, Liu Qi, Leng Qibin, Chen Lanming, Xie Lu
Abstract excerpt
BACKGROUND: Neoantigens can be differentially recognized by T cell receptor (TCR) as these sequences are derived from mutant proteins and are unique to the tumor. The discovery of neoantigens is the first key step for tumor-specific antigen (TSA) based immunotherapy. Based on high-throughput tumor genomic analysis, each missense mutation can potentially give rise to multiple neopeptides, resulting in a vast total...
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