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Obesity status modifies the association between rs7556897T>C in the intergenic region SLC19A3-CCL20 and blood pressure in French children.

Clinical chemistry and laboratory medicine - 25 Oct 2020

El Shamieh Said, Stathopoulou Maria G, Bonnefond Amélie, Ndiaye Ndeye Coumba, Lecoeur Cécile, Meyre David, Dadé Sébastien, Chedid Pia, Salami Ali, Shahabi Payman, Dedoussis George V, Froguel Philippe, Visvikis-Siest Sophie

Abstract excerpt

Background Growing evidence reports an association between inflammatory markers, obesity and blood pressure (BP). Specifically, the intergenic single nucleotide polymorphism (SNP) rs7556897T > C (MAF = 0.34) located between SLC19A3 and the CCL20 was shown to be associated with chronic inflammatory diseases. In addition, CCL20 expression was found increased in pancreatic islets of obese rodents and human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32238601
DOI: 10.1515/cclm-2019-0292

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