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Article

Nephrotoxic Effects in Zebrafish after Prolonged Exposure to Aristolochic Acid

30 Mar 2020

Abstract excerpt

With the aim to explore the possibility to generate a zebrafish model of renal fibrosis, in this study the fibrogenic renal effect of aristolochic acid I (AAI) after immersion was assessed. This compound is highly nephrotoxic able to elicit renal fibrosis after exposure of rats and humans. Our results reveal that larval zebrafish at 15 days dpf (days post-fertilization) exposed for 8 days to 0.5 µM AAI showed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32235450
DOI: 10.3390/toxins12040217

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