Article
Clinical and genetic investigation of pediatric cases of Wolff-Parkinson-White syndrome in Tunisian families.
Heart & lung : the journal of critical care - 1 Jan 2000
Nouira Sonia, Ouarda Fatma, Charfeddine Cherine, Arfa Imen, Ouragini Houyem, Abid Fekria, Abdelhak Sonia
Abstract excerpt
BACKGROUND: Wolff-Parkinson-White (WPW) syndrome is an autosomal-dominant heart disease characterized by an accessory pathway that arises from an aberrant conduction from the atria to the ventricles. Several mutations within the PRKAG2 gene were shown to be responsible for WPW. This gene encodes the γ2 regulatory subunit of adenosine monophosphate (AMP)-activated protein kinase, which functions as a metabolic...
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