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Article

Co-aggregation and heritability of organ-specific autoimmunity: a population-based twin study.

European journal of endocrinology - 1 May 2020

Skov Jakob, Eriksson Daniel, Kuja-Halkola Ralf, Höijer Jonas, Gudbjörnsdottir Soffia, Svensson Ann-Marie, Magnusson Patrik K E, Ludvigsson Jonas F, Kämpe Olle, Bensing Sophie

Abstract excerpt

OBJECTIVE: Co-aggregation of autoimmune diseases is common, suggesting partly shared etiologies. Genetic factors are believed to be important, but objective measures of environmental vs heritable influences on co-aggregation are absent. With a novel approach to twin studies, we aimed at estimating heritability and genetic overlap in seven organ-specific autoimmune diseases. DESIGN: Prospective twin cohort study....

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Identifiers

PMID: 32229696
DOI: 10.1530/EJE-20-0049
PMCID: PMC7182094

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