Article
Genetic polymorphisms of transient receptor potential melastatin 1 correlate with voriconazole-related visual adverse events.
Mycoses - 1 Jun 2020
Jiang Ying-Kui, Wang Rui-Ying, Wang Xuan, Zhao Hua-Zhen, Zhou Ling-Hong, Huang Li-Ping, Yip Ching-Wan, Cheng Jia-Hui, Que Chun-Xing, Jiang Chen, Zhu Li-Ping
Abstract excerpt
BACKGROUND: Causes of voriconazole-related visual adverse events (VVAE) remained controversial. OBJECTIVES: We aimed to explore the relationship between voriconazole serum concentrations and VVAE as well as the potential influence of transient receptor potential melastatin 1 (TRPM1) on VVAE. PATIENTS/METHODS: This prospective observational cohort study was done in two stages. Patients who received voriconazole...
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