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Article

Isoform-Selective KCNA1 Potassium Channel Openers Built from Glycine.

The Journal of pharmacology and experimental therapeutics - 1 Jun 2020

Manville Rían W, Abbott Geoffrey W

Abstract excerpt

Loss of function of voltage-gated potassium (Kv) channels is linked to a range of lethal or debilitating channelopathies. New pharmacological approaches are warranted to isoform-selectively activate specific Kv channels. One example is KCNA1 Potassium Voltage-Gated Channel Subfamily A Member 1 (KCNA1) (Kv1.1), an archetypal Shaker-type Kv channel, in which loss-of-function mutations cause episodic ataxia type 1...

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Identifiers

PMID: 32217768
DOI: 10.1124/jpet.119.264507
PMCID: PMC7228494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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