Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma.

doi:10.1038/s41591-020-1125-8

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Article

Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma.

Nature medicine - 1 Jan 2021

Wang Ruiping, Dang Minghao, Harada Kazuto, Han Guangchun, Wang Fang, Pool Pizzi Melissa, Zhao Meina, Tatlonghari Ghia, Zhang Shaojun, Hao Dapeng, Lu Yang, Zhao Shuangtao, Badgwell Brian D, Blum Murphy Mariela, Shanbhag Namita, Estrella Jeannelyn S, Roy-Chowdhuri Sinchita, Abdelhakeem Ahmed Adel Fouad, Wang Yuanxin, Peng Guang, Hanash Samir, Calin George A, Song Xingzhi, Chu Yanshuo, Zhang Jianhua, Li Mingyao, Chen Ken, Lazar Alexander J, Futreal Andrew, Song Shumei, Ajani Jaffer A, Wang Linghua

Abstract excerpt

Intratumoral heterogeneity (ITH) is a fundamental property of cancer; however, the origins of ITH remain poorly understood. We performed single-cell transcriptome profiling of peritoneal carcinomatosis (PC) from 15 patients with gastric adenocarcinoma (GAC), constructed a map of 45,048 PC cells, profiled the transcriptome states of tumor cell populations, incisively explored ITH of malignant PC cells and...

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PMID: 33398161
DOI: 10.1038/s41591-020-1125-8
PMCID: PMC8074162

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