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Article

Crystal structure of pathogenic Staphylococcus aureus lipase complex with the anti-obesity drug orlistat.

Scientific reports - 25 Mar 2020

Kitadokoro Kengo, Tanaka Mutsumi, Hikima Takaaki, Okuno Yukiko, Yamamoto Masaki, Kamitani Shigeki

Abstract excerpt

Staphylococcus aureus lipase (SAL), a triacylglycerol esterase, is an important virulence factor and may be a therapeutic target for infectious diseases. Herein, we determined the 3D structure of native SAL, the mutated S116A inactive form, and the inhibitor complex using the anti-obesity drug orlistat to aid in drug development. The determined crystal structures showed a typical α/β hydrolase motif with a...

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Identifiers

PMID: 32214208
DOI: 10.1038/s41598-020-62427-8
PMCID: PMC7096528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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