Article
Everolimus Rescues the Phenotype of Elastin Insufficiency in Patient Induced Pluripotent Stem Cell-Derived Vascular Smooth Muscle Cells.
Arteriosclerosis, thrombosis, and vascular biology - 1 May 2020
Kinnear Caroline, Agrawal Rahul, Loo Caitlin, Pahnke Aric, Rodrigues Deivid Carvalho, Thompson Tadeo, Akinrinade Oyediran, Ahadian Samad, Keeley Fred, Radisic Milica, Mital Seema, Ellis James
Abstract excerpt
OBJECTIVE: Elastin gene deletion or mutation leads to arterial stenoses due to vascular smooth muscle cell (SMC) proliferation. Human induced pluripotent stem cells-derived SMCs can model the elastin insufficiency phenotype in vitro but show only partial rescue with rapamycin. Our objective was to identify drug candidates with superior efficacy in rescuing the SMC phenotype in elastin insufficiency patients....
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