Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human CYP2E1-activated mutagenicity of dioxin-like PCBs 105 and 118-Experimental data consistent with molecular docking results.

Toxicology - 15 May 2020

Hu Keqi, Yu Hang, Li Zihuan, Jin Guifang, Jia Hansi, Song Meiqi, Liu Yungang

Abstract excerpt

Polychlorinated biphenyls (PCBs) are persistent organic pollutants with human carcinogenicity. Many lower chlorinated and non-dioxin-like PCBs have been observed to be mutagenic following activation by human CYP2E1, while activation of dioxin-like (DL-) PCBs by this enzyme has never been evidenced. In this study, each DL-PCB was analyzed by molecular docking to human CYP2E1 protein for predicting a substrate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cricetulus

Share to Cytochrome P-450 CYP2E1

Share to Hep G2 Cells

Share to Micronuclei, Chromosome-Defective

Share to Molecular Docking Simulation

Share to Polychlorinated Biphenyls

Source

Identifiers

PMID: 32199159
DOI: 10.1016/j.tox.2020.152438

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human CYP2E1-activated mutagenicity of dioxin-like PCBs 105 and 118-Experimental data consistent with molecular docking results.PMID 32199159Read ↗

Potent mutagenicity of some non-planar tri- and tetrachlorinated biphenyls in mammalian cells, human CYP2E1 being a major activating enzyme.Semantic proximity Read ↗

Featured structure-activity relationships for some tri- and tetrachlorobiphenyls in human CYP2E1-activated mutagenicity - Impact of the extent of ortho-chlorination.Semantic proximity Read ↗

Induction of micronuclei and cell cycle arrest by some tri- and tetrachlorobiphenyls in mammalian cells deficient in xenobiotic-metabolizing enzymes.Semantic proximity Read ↗

The essential role of GSTP1 I105V polymorphism in the prediction of CDNB metabolism and toxicity: In silico and in vitro insights.Semantic proximity Read ↗

Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells.Semantic proximity Read ↗

Biomonitoring of Human Population Exposure to Environmental Genotoxic Chemicals: the EEC Project.Semantic proximity Read ↗

Quinoid metabolites of 4-monochlorobiphenyl induce gene mutations in cultured Chinese hamster v79 cells.Semantic proximity Read ↗

Evaluation of 4-hydroxymethylbiphenyl (4HMB), 4-chloromethylbiphenyl (4CMB) and benzyl chloride (BC) using the Ames Salmonella/microsome incorporation test for mutagenicity.Semantic proximity Read ↗

Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample.Semantic proximity Read ↗

Induction of clastogenesis and gene mutations by carbamazepine (at its therapeutically effective serum levels) in mammalian cells and the dependence on human CYP2B6 enzyme activity.Semantic proximity Read ↗

In Silico Methods for Chromosome Damage.Semantic proximity Read ↗

Cytochrome CYP2E1 phenotyping and genotyping in the evaluation of health risks from exposure to polluted environments.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.