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CRISPR-Cas9 Dual-gRNA Attack Causes Mutation, Excision and Inversion of the HIV-1 Proviral DNA.

Viruses - 18 Mar 2020

Binda Caroline S, Klaver Bep, Berkhout Ben, Das Atze T

Abstract excerpt

Although several studies demonstrated that the HIV proviral DNA can be effectively targeted and inactivated by the CRISPR-Cas9 system, the precise inactivation mechanism has not yet been analyzed. Whereas some studies suggested efficient proviral DNA excision upon dual-gRNA/Cas9 treatment, we previously demonstrated that hypermutation of the target sites correlated with permanent virus inactivation. To better...

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PMID: 32197474
DOI: 10.3390/v12030330
PMCID: PMC7150824

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