Article
Surfactant-enhanced DNA accessibility to nuclease accelerates phenotypic β-lactam antibiotic susceptibility testing of Neisseria gonorrhoeae.
PLoS biology - 1 Mar 2020
Savela Emily S, Schoepp Nathan G, Cooper Matthew M, Rolando Justin C, Klausner Jeffrey D, Soge Olusegun O, Ismagilov Rustem F
Abstract excerpt
Rapid antibiotic susceptibility testing (AST) for Neisseria gonorrhoeae (Ng) is critically needed to counter widespread antibiotic resistance. Detection of nucleic acids in genotypic AST can be rapid, but it has not been successful for β-lactams (the largest antibiotic class used to treat Ng). Rapid phenotypic AST for Ng is challenged by the pathogen's slow doubling time and the lack of methods to quickly...
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