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Differential DNA accessibility to polymerase enables 30-minute phenotypic β-lactam antibiotic susceptibility testing of carbapenem-resistant Enterobacteriaceae.

PLoS biology - 1 Mar 2020

Schoepp Nathan G, Liaw Eric J, Winnett Alexander, Savela Emily S, Garner Omai B, Ismagilov Rustem F

Abstract excerpt

The rise in carbapenem-resistant Enterobacteriaceae (CRE) infections has created a global health emergency, underlining the critical need to develop faster diagnostics to treat swiftly and correctly. Although rapid pathogen-identification (ID) tests are being developed, gold-standard antibiotic susceptibility testing (AST) remains unacceptably slow (1-2 d), and innovative approaches for rapid phenotypic ASTs for...

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PMID: 32191697
DOI: 10.1371/journal.pbio.3000652
PMCID: PMC7081982

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