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Article

Alterations in the methylome of the stromal tumour microenvironment signal the presence and severity of prostate cancer

18 Mar 2020

Abstract excerpt

BACKGROUND: Prostate cancer changes the phenotype of cells within the stromal microenvironment, including fibroblasts, which in turn promote tumour progression. Functional changes in prostate cancer-associated fibroblasts (CAFs) coincide with alterations in DNA methylation levels at loci-specific regulatory regions. Yet, it is not clear how these methylation changes compare across CAFs from different patients....

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PMID: 32188493
DOI: 10.1186/s13148-020-00836-2

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