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Article

Translation of mouse model to human gives insights into periodontitis etiology.

Scientific reports - 17 Mar 2020

Nashef Aysar, Matthias Munz, Weiss Ervin, Loos Bruno G, Jepsen Søren, van der Velde Nathalie, Uitterlinden André G, Wellmann Jürgen, Berger Klaus, Hoffmann Per, Laudes Matthias, Lieb Wolfgang, Franke Andre, Dommisch Henrik, Schäfer Arne, Houri-Haddad Yael, Iraqi Fuad A

Abstract excerpt

To suggest candidate genes involved in periodontitis, we combined gene expression data of periodontal biopsies from Collaborative Cross (CC) mouse lines, with previous reported quantitative trait loci (QTL) in mouse and with human genome-wide association studies (GWAS) associated with periodontitis. Periodontal samples from two susceptible, two resistant and two lines that showed bone formation after periodontal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32184465
DOI: 10.1038/s41598-020-61819-0
PMCID: PMC7078197

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