Article
A SNP in the 3'UTR of the porcine IGF-1 gene interacts with miR-new14 to affect IGF-1 expression, proliferation and apoptosis of PK-15 cells.
Domestic animal endocrinology - 1 Jul 2020
Song Jie, Hao Linlin, Wei Wenzhen, Yang Rui, Wang Chunli, Geng Hongwei, Li Haoyang, Wang Siyao, Lu Guanhong, Feng Tianqi, Sun Xiaotong, Liu Songcai, Wang Gang, Cheng Yunyun
Abstract excerpt
The kidney of miniature pigs has been considered the most likely potential kidney source for patients needing kidney transplantation. Insulin-like growth factor 1 (IGF-1) is involved in regulating the growth of miniature pigs and inducing growth of kidneys. There are evidences showing that the SNPs in the 3'UTR of a gene may affect the gene expression by affecting the binding to a miRNA target site. In this...
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