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Article

Porcine IGF-1R synonymous mutations in the intracellular domain affect cell proliferation and alter kinase activity.

International journal of biological macromolecules - 1 Jun 2020

Wang Chunli, Liu Songcai, Wu Qingyan, Cheng Yunyun, Feng Tianqi, Song Jie, Yang Rui, Geng Hongwei, Lu Guanhong, Wang Siyao, Hao Linlin

Abstract excerpt

Miniature pigs are regarded as ideal organ donors for xenotransplantation into humans. Elucidating the formation mechanism of miniature pigs is important. The insulin-like growth factor 1 receptor (IGF-1R) is crucial in the regulation of cell proliferation and organismal growth. According to our previous research, the IGF-1R expression levels between large and miniature pigs showed different profiles in liver and...

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Identifiers

PMID: 32109480
DOI: 10.1016/j.ijbiomac.2020.02.281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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