Article
Curcumin β-D-glucuronide exhibits anti-tumor effects on oxaliplatin-resistant colon cancer with less toxicity in vivo.
Cancer science - 1 May 2020
Ozawa-Umeta Hitomi, Kishimoto Atsuhiro, Imaizumi Atsushi, Hashimoto Tadashi, Asakura Tadashi, Kakeya Hideaki, Kanai Masashi
Abstract excerpt
The NF-kappa B (NF-κB) pathway plays a pivotal role in tumor progression and chemoresistance, and its inhibition has been shown to suppress tumor growth in a variety of preclinical models. Recently, we succeeded in synthesizing a water-soluble injectable type of curcumin β-D-glucuronide (CMG), which is converted into a free-form of curcumin by β-glucuronidase in vivo. Herein, we aimed to clarify the efficacy,...
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