Dicer-2 Regulates Resistance and Maintains Homeostasis against Zika Virus Infection in Drosophila

Abstract excerpt

Abstract Zika virus (ZIKV) outbreaks pose a massive public health threat in several countries. We have developed an in vivo model to investigate the host–ZIKV interaction in Drosophila. We have found that a strain of ZIKV replicates in wild-type flies without reducing their survival ability. We have shown that ZIKV infection triggers RNA interference and that mutating Dicer-2 results in enhanced ZIKV load and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Insect symbiosis and bacterial influences
• Share to Invertebrate Immune Response Mechanisms
• Share to Mosquito-borne diseases and control