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Article

Mutations in a Single Signaling Pathway Allow Cell Growth in Heavy Water.

ACS synthetic biology - 17 Apr 2020

Kampmeyer Caroline, Johansen Jens V, Holmberg Christian, Karlson Magnus, Gersing Sarah K, Bordallo Heloisa N, Kragelund Birthe B, Lerche Mathilde H, Jourdain Isabelle, Winther Jakob R, Hartmann-Petersen Rasmus

Abstract excerpt

Life is completely dependent on water. To analyze the role of water as a solvent in biology, we replaced water with heavy water (D2O) and investigated the biological effects by a wide range of techniques, using Schizosaccharomyces pombe as model organism. We show that high concentrations of D2O lead to altered glucose metabolism and growth retardation. After prolonged incubation in D2O, cells displayed gross...

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PMID: 32142608
DOI: 10.1021/acssynbio.9b00376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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