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Article

Epstein-Barr virus-positive gastric cancer involves enhancer activation through activating transcription factor 3.

Cancer science - 1 May 2020

Asakawa Yuta, Okabe Atsushi, Fukuyo Masaki, Li Wenzhe, Ikeda Eriko, Mano Yasunobu, Funata Sayaka, Namba Hiroe, Fujii Takahiro, Kita Kazuko, Matsusaka Keisuke, Kaneda Atsushi

Abstract excerpt

Epstein-Barr virus (EBV) is associated with particular forms of gastric cancer (GC). We previously showed that EBV infection into gastric epithelial cells induced aberrant DNA hypermethylation in promoter regions and silencing of tumor suppressor genes. We here undertook integrated analyses of transcriptome and epigenome alteration during EBV infection in gastric cells, to investigate activation of enhancer...

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Apoptosis
Enhancer Elements, Genetic
Epigenome
Epstein-Barr Virus Infections
Epstein-Barr Virus Nuclear Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Herpesvirus 4, Human

Stomach Neoplasms

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PMID: 32119176
DOI: 10.1111/cas.14370
PMCID: PMC7226279

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