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Comprehensive mutanome analysis of Lewis lung cancer reveals immunogenic neoantigens for therapeutic vaccines.

Biochemical and biophysical research communications - 7 May 2020

Chen Tao, Hu Ruiqi, Wan Ying, Sun Fengzeng, Wang Zichen, Yue Junqiu, Chen Jian, Han Guang, Wei Guangwei, Dong Zhiqiang

Abstract excerpt

Personalized neoantigen vaccines are capable of eliciting vigorous T-cell responses and have been demonstrated to achieve striking therapeutic effects against cancer. Here we performed comprehensive mutanome analysis of the mouse Lewis lung cancer cells to identify tumor neoantigens followed by prediction of their MHC affinity and immunogenicity. We adopted a strategy that enables us to select neoantigens that...

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PMID: 32115148
DOI: 10.1016/j.bbrc.2020.02.132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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