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Article

Combined Small and Squamous Transformation in EGFR-mutated Lung Adenocarcinoma.

Internal medicine (Tokyo, Japan) - 15 May 2020

Hakozaki Taiki, Kitazono Miyako, Takamori Mikio, Kiriu Takahiro

Abstract excerpt

Histologic transformation has been described as an acquired mechanism of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). We herein report the case of a woman with stage IV lung adenocarcinoma harboring EGFR exon 19 deletions who was initially treated with EGFR-TKIs; several cytotoxic chemotherapeutic regimens were used when resistance developed. A lymph node re-biopsy...

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Identifiers

PMID: 32101830
DOI: 10.2169/internalmedicine.3542-19
PMCID: PMC7303443

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