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Article

Thyroid Hormone Analogues: An Update.

Thyroid : official journal of the American Thyroid Association - 1 Aug 2020

Zucchi Riccardo

Abstract excerpt

The development of thyroid hormone (TH) analogues was prompted by the attempt to exploit the effects of TH on lipid metabolism, avoiding cardiac thyrotoxicosis. Analysis of the relative distribution of the α and β subtypes of nuclear TH receptors (TRα and TRβ) showed that TRα and TRβ are responsible for cardiac and metabolic responses, respectively. Therefore, analogues with TRβ selectivity were developed, and...

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Identifiers

PMID: 32098589
DOI: 10.1089/thy.2020.0071
PMCID: PMC7415871

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