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Article

Inuit metabolism revisited: what drove the selective sweep of CPT1a L479?

Molecular genetics and metabolism - 1 Apr 2020

Hale Nicola

Abstract excerpt

This article reassesses historical studies of Inuit metabolism in light of recent developments in evolutionary genetics. It discusses the possible selective advantage of a variant of CPT1a, which encodes the rate limiting enzyme in hepatic fatty acid oxidation. The L479 variant of CPT1a underwent one of the strongest known selective sweeps in human history and is specific to Inuit and Yu'pik populations. Recent...

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Source

Identifiers

PMID: 32088118
DOI: 10.1016/j.ymgme.2020.01.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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