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Article

Glycine receptor antibodies in stiff-person syndrome and other GAD-positive CNS disorders

31 Oct 2013

Abstract excerpt

Stiff-person syndrome (SPS) is characterized by stiffness in trunk and limb muscles, phobic anxiety, and sudden spasms. A disturbance in inhibitory GABAergic pathways, presumably by autoantibodies against GAD (the main GABA-synthesizing enzyme), is considered fundamental for SPS pathogenesis.1 As the precise role of anti-GAD antibodies in SPS remains unclear,2,3 several other candidate disease-specific...

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PMID: 24174585
DOI: 10.1212/01.wnl.0000436617.40779.65

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