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Article

Three-dimensional culture models mimic colon cancer heterogeneity induced by different microenvironments.

Scientific reports - 21 Feb 2020

Kawai Shigeto, Yamazaki Masaki, Shibuya Keita, Yamazaki Masaya, Fujii Etsuko, Nakano Kiyotaka, Suzuki Masami

Abstract excerpt

Colorectal cancer demonstrates intra-tumour heterogeneity formed by a hierarchical structure comprised of cancer stem cells (CSCs) and their differentiated progenies. The mechanism by which CSCs are maintained and differentiated needs to be further elucidated, and there is evidence that the tumour microenvironment governs cancer stemness. Using PLR123, a colon cancer cell line with CSC properties, we determined...

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Source

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Identifiers

PMID: 32081957
DOI: 10.1038/s41598-020-60145-9
PMCID: PMC7035265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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