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Article

Transcriptome analysis reveals the difference between "healthy" and "common" aging and their connection with age-related diseases.

Aging cell - 1 Mar 2020

Zeng Lu, Yang Jialiang, Peng Shouneng, Zhu Jun, Zhang Bin, Suh Yousin, Tu Zhidong

Abstract excerpt

A key goal of aging research was to understand mechanisms underlying healthy aging and develop methods to promote the human healthspan. One approach is to identify gene regulations unique to healthy aging compared with aging in the general population (i.e., "common" aging). Here, we leveraged Genotype-Tissue Expression (GTEx) project data to investigate "healthy" and "common" aging gene expression regulations at...

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PMID: 32077223
DOI: 10.1111/acel.13121
PMCID: PMC7059150

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