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Article

ROCK1 activation-mediated mitochondrial translocation of Drp1 and cofilin are required for arnidiol-induced mitochondrial fission and apoptosis.

Journal of experimental & clinical cancer research : CR - 19 Feb 2020

Hu Jinjiao, Zhang Hongwei, Li Jie, Jiang Xiuxing, Zhang Yanhao, Wu Qin, Shen Liwen, Shi Jingshan, Gao Ning

Abstract excerpt

BACKGROUND: Arnidiol is a pentacyclic triterpene diol that has multiple pharmacological activities. However, the apoptotic activities of arnidiol in human cancer cells have not yet been explored, nor has the mechanism by which arnidiol induces apoptosis been examined in depth. METHODS: MDA-MB-231 cells and xenografted mice were treated with arnidiol. Mitochondrial fission and apoptosis were determined by...

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Identifiers

PMID: 32075676
DOI: 10.1186/s13046-020-01545-7
PMCID: PMC7031977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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