Article
Primary structure of human neutrophil antigens 1a and 1b.
Transfusion - 1 Apr 2020
Sachs Ulrich J, Radke Clemens, Bein Gregor, Grabowski Claudia, Simtong Piyapong, Bux Jürgen, Bayat Behnaz, Reil Angelika
Abstract excerpt
BACKGROUND: Neutrophil specific Fcγ receptor IIIb (CD16b) is a low-affinity IgG receptor. Its polymorphic variants are associated with human neutrophil antigens (HNA). HNA-1a and HNA-1b differ in four amino acids. Immunization can lead to the production of alloantibodies. The exact contribution of four amino acid exchanges for the formation of HNA-1a, -1b epitopes is currently unknown. STUDY DESIGN AND METHODS:...
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