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Article

Upregulation of SMYD3 and SMYD3 VNTR 3/3 polymorphism increase the risk of hepatocellular carcinoma.

Scientific reports - 18 Feb 2020

Binh Mai Thanh, Hoan Nghiem Xuan, Giang Dao Phuong, Tong Hoang Van, Bock C-Thomas, Wedemeyer Heiner, Toan Nguyen Linh, Bang Mai Hong, Kremsner Peter G, Meyer Christian G, Song Le Huu, Velavan Thirumalaisamy P

Abstract excerpt

SMYD3 (SET and MYND domain-containing protein 3) is involved in histone modification, which initiates oncogenesis by activating transcription of multiple downstream genes. To investigate associations of variable numbers of tandem repeats (VNTR) variants in the SMYD3 gene promoter, SMYD3 serum levels and SMYD3 mRNA expression in hepatitis B virus (HBV) infection and clinical progression of related liver disease....

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Share to Carcinoma, Hepatocellular
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B, Chronic

Share to Histone-Lysine N-Methyltransferase

Share to Liver Cirrhosis

Share to Liver Neoplasms

Share to Minisatellite Repeats

Share to Promoter Regions, Genetic

Source

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Identifiers

PMID: 32071406
DOI: 10.1038/s41598-020-59667-z
PMCID: PMC7029004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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