Article
Molecular and immunohistochemical characterization reveals novel BRAF mutations in metanephric adenoma.
The American journal of surgical pathology - 1 Apr 2015
Udager Aaron M, Pan Jincheng, Magers Martin J, Palapattu Ganesh S, Morgan Todd M, Montgomery Jeffrey S, Weizer Alon Z, Hafez Khaled S, Miller David C, Wolf James S, McHugh Jonathan B, Chinnaiyan Arul M, Dhanasekaran Saravana M, Mehra Rohit
Abstract excerpt
Metanephric adenoma (MA) is a rare benign renal tumor comprised of a neoplastic proliferation of primitive metanephric tubular cells. A previous study identified BRAF V600E mutations in approximately 90% of MA and found that similar BRAF exon 15 mutations are exceedingly rare in other common renal tumors, including renal cell carcinoma and oncocytoma. A recent follow-up study has validated mutation-specific...
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