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Article

Analysis of the dynamics of Staphylococcus aureus binding to white blood cells using whole blood assay and geno-to-pheno mapping.

International journal of medical microbiology : IJMM - 1 Apr 2020

Gaidar Daria, Jonas Alice, Akulenko Ruslan, Ruffing Ulla, Herrmann Mathias, Helms Volkhard, von Müller Lutz

Abstract excerpt

Given that binding and internalization of bacteria to host cells promotes infections and invasion, we aimed at characterizing how various S. aureus isolates adhere to and are internalized by different white blood cells. In particular, the role of genetic determinants on the association kinetics should be unveiled. A flow cytometric (FACS) whole blood assay with fluorescently labelled isolates was applied to 56...

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Identifiers

PMID: 32061541
DOI: 10.1016/j.ijmm.2020.151411

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