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Article

Testicular expression of TDRD1, TDRD5, TDRD9 and TDRD12 in azoospermia

14 Feb 2020

Abstract excerpt

BACKGROUND: Tudor domain-containing proteins (TDRDs) play a critical role in piRNA biogenesis and germ cell development. piRNAs, small regulatory RNAs, act by silencing of transposons during germline development and it has recently been shown in animal model studies that defects in TDRD genes can lead to sterility in males. METHODS: Here we evaluate gene and protein expression levels of four key TDRDs (TDRD1,...

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PMID: 32059713
DOI: 10.1186/s12881-020-0970-0

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