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Article

Genetic polymorphism in MDR1 C3435T is a determinant of methotrexate cerebrospinal fluid concentrations in Chinese children with acute lymphoblastic leukemia .

International journal of clinical pharmacology and therapeutics - 1 May 2020

Zhang Yu-Xin, Ma Yu, Zhang Hao, Zhang Wen-Ping, Yang Xiao-Ying

Abstract excerpt

AIM: This study aimed to investigate the inﬂuence of single-nucleotide polymorphism in exon 26 (C3435T) of multidrug resistance 1 (MDR1) transporter gene on the concentration of methotrexate (MTX) in Chinese childhood patients with acute lymphoblastic leukemia (ALL) receiving intravenous (IV) and intrathecal (IT) high-dose methotrexate (HDMTX) chemotherapy. MATERIALS AND METHODS: MDR1 C3435T polymorphism was...

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Identifiers

PMID: 32053102
DOI: 10.5414/CP203462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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