Association of leptin and leptin receptor polymorphisms with coronary artery disease in a North Chinese Han population.

doi:10.1590/0037-8682-0388-2019

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Article

Association of leptin and leptin receptor polymorphisms with coronary artery disease in a North Chinese Han population.

Revista da Sociedade Brasileira de Medicina Tropical - 1 Jan 2020

Wang Haidong, Wang Chao, Han Wenxiu, Geng Chunmei, Chen Dan, Wu Bin, Zhang Jun, Wang Changshui, Jiang Pei

Abstract excerpt

INTRODUCTION: Leptin (LEP) is a peptide hormone that acts via leptin receptor (LEPR) binding. Genetic evidence from different human populations has implicated LEP/LEPR in the pathogenesis of coronary artery disease (CAD), and suggests that certain LEP/LEPR gene polymorphisms may increase the risk of CAD. The aim of this study was to assess two single nucleotide polymorphisms (SNPs) in LEP genes (rs2167270 and...

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PMID: 32049202
DOI: 10.1590/0037-8682-0388-2019
PMCID: PMC7083392

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