Article
A fast-linear mixed model for genome-wide haplotype association analysis: application to agronomic traits in maize.
BMC genomics - 11 Feb 2020
Chen Heli, Hao Zhiyu, Zhao Yunfeng, Yang Runqing
Abstract excerpt
BACKGROUND: Haplotypes combine the effects of several single nucleotide polymorphisms (SNPs) with high linkage disequilibrium, which benefit the genome-wide association analysis (GWAS). In the haplotype association analysis, both haplotype alleles and blocks are tested. Haplotype alleles can be inferred with the same statistics as SNPs in the linear mixed model, while blocks require the formulation of unified...
Topics
- Genome-Wide Association Study
- Haplotypes
- Linear Models
- Polymorphism, Single Nucleotide
- Zea mays