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Article

A rapid pyrosequencing assay for the molecular detection of influenza viruses with reduced baloxavir susceptibility due to PA/I38X amino acid substitutions.

Influenza and other respiratory viruses - 1 Jul 2020

Koszalka Paulina, Farrukee Rubaiyea, Mifsud Edin, Vijaykrishna Dhanasekaran, Hurt Aeron C

Abstract excerpt

Baloxavir marboxil is a novel endonuclease inhibitor licensed for treatment of otherwise healthy or high-risk individuals infected with influenza. Viruses with reduced baloxavir susceptibility due to amino acid substitutions at residue 38 of the PA have been detected in some individuals following treatment. Here, we describe a genotypic pyrosequencing method that can be used to rapidly screen circulating...

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PMID: 32045100
DOI: 10.1111/irv.12725
PMCID: PMC7298287

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