Article
Inverse Association Between the Quantity of Human Peripheral Blood CXCR5+IFN-γ+CD8+ T Cells With De Novo DSA Production in the First Year After Kidney Transplant.
Transplantation - 1 Nov 2020
Zimmerer Jason M, Basinger Matthew W, Ringwald Bryce A, Abdel-Rasoul Mahmoud, Pelletier Ronald P, Rajab Amer, El-Hinnawi Ashraf, Parekh Hemant, Washburn Kenneth, Bumgardner Ginny L
Abstract excerpt
BACKGROUND: We recently reported that a novel CXCR5IFN-γCD8 T-cell subset significantly inhibits posttransplant alloantibody production in a murine transplant model. These findings prompted the current study to investigate the association of human CD8 T cells with the same phenotype with the development of de novo donor-specific antibody (DSA) after kidney transplantation. METHODS: In the current studies, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.