Bone morphogenetic protein 9, and its genetic variants contribute to susceptibility of idiopathic pulmonary arterial hypertension.

doi:10.18632/aging.102726

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Article

Bone morphogenetic protein 9, and its genetic variants contribute to susceptibility of idiopathic pulmonary arterial hypertension.

Aging - 7 Feb 2020

Guo Kefang, Xu Liying, Jin Lin, Wang Huilin, Ren Yun, Hu Yan, Yu Jing, Cang Jing

Abstract excerpt

Considering the predominant role of rare variants of the Bone morphogenetic protein 9 (BMP9) gene in the occurrence of idiopathic pulmonary arterial hypertension (IPAH), here we conducted a case-control study, together with functional validation, to explore the relationships between variants of the BMP9 gene and development of IPAH. We found minor alleles of rs3740297 (OR: 0.72, 95% CI: 0.59-0.87, P=7.77×10-5)...

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PMID: 32031986
DOI: 10.18632/aging.102726
PMCID: PMC7041772

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