Article
Moxifloxacin and Sitafloxacin Treatment Failure in Mycoplasma genitalium Infection: Association with parC Mutation G248T (S83I) and Concurrent gyrA Mutations.
The Journal of infectious diseases - 2 Mar 2020
Murray Gerald L, Bodiyabadu Kaveesha, Danielewski Jennifer, Garland Suzanne M, Machalek Dorothy A, Fairley Christopher K, Jensen Jørgen S, Williamson Deborah A, Tan Lit Y, Mokany Elisa, Durukan Duygu, Bradshaw Catriona S
Abstract excerpt
BACKGROUND: The basis of fluoroquinolone treatment failure for Mycoplasma genitalium is poorly understood. METHODS: To identify mutations associated with failure we sequenced key regions of the M. genitalium parC and gyrA genes for patients undergoing sequential therapy with doxycycline-moxifloxacin (201 patients, including 21 with failure) or doxycycline-sitafloxacin (126 patients, including 13 with failure)....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.