gyrA Mutations in Mycoplasma genitalium and Their Contribution to Moxifloxacin Failure: Time for the Next Generation of Resistance-Guided Therapy.

doi:10.1093/cid/ciad057

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Article

gyrA Mutations in Mycoplasma genitalium and Their Contribution to Moxifloxacin Failure: Time for the Next Generation of Resistance-Guided Therapy.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 16 Jun 2023

Murray Gerald L, Plummer Erica L, Bodiyabadu Kaveesha, Vodstrcil Lenka A, Huaman Jose L, Danielewski Jennifer A, Chua Teck Phui, Machalek Dorothy A, Garland Suzanne, Doyle Michelle, Sweeney Emma L, Whiley David M, Bradshaw Catriona S

Abstract excerpt

BACKGROUND: Although single nucleotide polymorphisms (SNPs) in Mycoplasma genitalium parC contribute to fluoroquinolone treatment failure, data are limited for the homologous gene, gyrA. This study investigated the prevalence of gyrA SNPs and their contribution to fluoroquinolone failure. METHODS: Samples from 411 patients (male and female) undergoing treatment for M. genitalium infection (Melbourne Sexual Health...

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Identifiers

PMID: 36722416
DOI: 10.1093/cid/ciad057
PMCID: PMC10273371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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