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Article

Granulins Regulate Aging Kinetics in the Adult Zebrafish Telencephalon.

Cells - 3 Feb 2020

Zambusi Alessandro, Pelin Burhan Özge, Di Giaimo Rossella, Schmid Bettina, Ninkovic Jovica

Abstract excerpt

Granulins (GRN) are secreted factors that promote neuronal survival and regulate inflammation in various pathological conditions. However, their roles in physiological conditions in the brain remain poorly understood. To address this knowledge gap, we analysed the telencephalon in Grn-deficient zebrafish and identified morphological and transcriptional changes in microglial cells, indicative of a pro-inflammatory...

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Identifiers

PMID: 32028681
DOI: 10.3390/cells9020350
PMCID: PMC7072227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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