Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases.

doi:10.1074/mcp.RA119.001860

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Article

Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases.

Molecular & cellular proteomics : MCP - 1 May 2020

Martin Tiphaine C, Šimurina Mirna, Ząbczyńska Marta, Martinic Kavur Marina, Rydlewska Magdalena, Pezer Marija, Kozłowska Kamila, Burri Andrea, Vilaj Marija, Turek-Jabrocka Renata, Krnjajić-Tadijanović Milena, Trofimiuk-Müldner Małgorzata, Ugrina Ivo, Lityńska Anna, Hubalewska-Dydejczyk Alicja, Trbojevic-Akmacic Irena, Lim Ee Mun, Walsh John P, Pocheć Ewa, Spector Tim D, Wilson Scott G, Lauc Gordan

Abstract excerpt

Autoimmune thyroid diseases (AITD) are the most common group of autoimmune diseases, associated with lymphocyte infiltration and the production of thyroid autoantibodies, like thyroid peroxidase antibodies (TPOAb), in the thyroid gland. Immunoglobulins and cell-surface receptors are glycoproteins with distinctive glycosylation patterns that play a structural role in maintaining and modulating their functions. We...

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PMID: 32024769
DOI: 10.1074/mcp.RA119.001860
PMCID: PMC7196582

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