Pleiotropic Effects of a KCNQ1 Variant on Lipid Profiles and Type 2 Diabetes: A Family-Based Study in China.

doi:10.1155/2020/8278574

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Article

Pleiotropic Effects of a KCNQ1 Variant on Lipid Profiles and Type 2 Diabetes: A Family-Based Study in China.

Journal of diabetes research - 1 Jan 2020

Wang Xiaowen, Wu Junhui, Wu Yao, Wang Mengying, Wang Zijing, Wu Tao, Chen Dafang, Tang Xun, Qin Xueying, Wu Yiqun, Hu Yonghua

Abstract excerpt

OBJECTIVE: The genetic variant rs2237895, located in the Potassium Voltage-Gated Channel Subfamily Q Member 1 (KCNQ1) gene, has been replicated to be associated with type 2 diabetes mellitus (T2DM) susceptibility, but the relationship with lipids is conflicting. Furthermore, the common genetic predisposition to T2DM and lipids was not fully detected. METHODS: In total, 5839 individuals (2220 were T2DM patients)...

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PMID: 32016123
DOI: 10.1155/2020/8278574
PMCID: PMC6982365

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