Article
Drosophila adult muscle precursor cells contribute to motor axon pathfinding and proper innervation of embryonic muscles.
Development (Cambridge, England) - 17 Feb 2020
Lavergne Guillaume, Zmojdzian Monika, Da Ponte Jean Philippe, Junion Guillaume, Jagla Krzysztof
Abstract excerpt
Despites several decades of studies on the neuromuscular system, the relationship between muscle stem cells and motor neurons remains elusive. Using the Drosophila model, we provide evidence that adult muscle precursors (AMPs), the Drosophila muscle stem cells, interact with the motor axons during embryogenesis. AMPs not only hold the capacity to attract the navigating intersegmental (ISN) and segmental a (SNa)...
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