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Article

Polymerase independent repression of FoxO1 transcription by sequence-specific PARP1 binding to FoxO1 promoter.

Cell death & disease - 28 Jan 2020

Tian Yu-Nan, Chen Hua-Dong, Tian Chang-Qing, Wang Ying-Qing, Miao Ze-Hong

Abstract excerpt

Poly(ADP-ribose) polymerase 1 (PARP1) regulates gene transcription in addition to functioning as a DNA repair factor. Forkhead box O1 (FoxO1) is a transcription factor involved in extensive biological processes. Here, we report that PARP1 binds to two separate motifs on the FoxO1 promoter and represses its transcription in a polymerase-independent manner. Using PARP1-knock out (KO) cells,...

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Identifiers

PMID: 31992690
DOI: 10.1038/s41419-020-2265-y
PMCID: PMC6987093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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