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Development and Characterization of Efficient Cell Culture Systems for Genotype 1 Hepatitis E Virus and Its Infectious cDNA Clone.

Viruses - 26 Mar 2023

Primadharsini Putu Prathiwi, Nagashima Shigeo, Tanaka Toshinori, Jirintai Suljid, Takahashi Masaharu, Murata Kazumoto, Okamoto Hiroaki

Abstract excerpt

Hepatitis E virus (HEV) is a major cause of acute viral hepatitis globally. Genotype 1 HEV (HEV-1) is responsible for multiple outbreaks in developing countries, causing high mortality rates in pregnant women. However, studies on HEV-1 have been hindered by its poor replication in cultured cells. The JE04-1601S strain recovered from a Japanese patient with fulminant hepatitis E who contracted HEV-1 while...

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Identifiers

PMID: 37112827
DOI: 10.3390/v15040845
PMCID: PMC10146093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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